Purmorphamine (CAS 483367-10-8) induces osteogenesis in multipotent mesenchymal progenitor cells via activation of hedgehog signaling.1,2 Activation of hedgehog is achieved via direct targeting of Smoothened.3 Purmorphamine has also been used as part of a “cocktail” of small molecules to reprogram mouse somatic cells into pluripotent stem-like cells4 and human Astroglial cells into functional neurons5.
1) Wu et al. (2002), A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells; J. Am. Chem. Soc., 124 14520
2) Wu et al. (2004), Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway; Chem. Biol. 11 1229
3) Sinha and Chen (2006), Purmorphamine activates the Hedgehog pathway by targeting Smoothened; Nat. Chem. Biol., 2 29
4) Kang et al. (2015), Reprogramming of mouse somatic cells into pluripotent stem-like cells using a combination of small molecules; Biomaterials, 35 7336
5) Zhang et al. (2015), Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons; Cell Stem Cell 17 735