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Product Details

RepSox | TGFbetaR-1 / ALK5 inhibitor

RepSox (446859-33-2) is a potent (IC50 ALK5 auto-P= 4 nM; IC50 TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1 RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2 It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4


1) Gellibert et al. (2004), Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors; J.Med. Chem. 47 4494
2) Ichida et al. (2009), A Small-molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog; Cell Stem Cell 5 491
3) Cheng et al. (2015), Direct Conversion of astrocytes into neuronal cells by a drug cocktail; Cell Res. 25 1269
4) Cheng et al. (2014), Generation of neural progenitor cells by chemical cocktails and hypoxia; Cell Res. 24 665

Focus Biomolecules cell signaling supplier, chemical structure of RepSox | TGFbetaR-1 | ALK5 inhibitor | CAS 446859-33-2

Catalog#  10-4546-0005

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
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Catalog Number:
TGFβR-1 / ALK5 inhibitor
Chemical Name:
Alternate Names:
E-616452; SNJ 2511
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Pale yellow solid
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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