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Product Details

TRO19622 | Neurotrophic agent

TRO19622 (220033-87-0) is a neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP).1 Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage.2 Inhibits MPTP opening and protects neurons from apoptosis.3 Induces oligodendrocyte maturation in culture and promotes myelin regeneration in vivo in a rodent model.4

References/Citations

1) Bordet et al. (2007), Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis; J. Pharmacol. Exp. Ther., 322 709
2) Ma et al. (2014), NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage; Ann. Neurol., 75 209
3) Martin et al. (2011), The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation; J. Neurosci., 31 359
4) Magalon et al. (2016), Olesoxime favors oligodendrocyte differentiation through a functional interplay between mitochondria and microtubules; Neuropharmacology, 111 293

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Catalog#  10-3230-0005

$55.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
220033-87-0
Catalog Number:
10-3230
Activity:
Neurotrophic agent
Chemical Name:
Cholest-4-en-3-one oxime
Alternate Names:
Olesoxime
Molecular Weight:
399.65
Molecular Formula:
C27H45NO
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
FeaturedDescription:
Neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP)
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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