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Ginkgolide B | PAF receptor antagonist

Ginkgolide B (15291-77-7) is a PAF receptor antagonist (Ki = 1.3 μM)1. Inhibits neutrophil degranulation and superoxide production in vitro1. Inhibits PAF-induced bronchoconstriction in a guinea pig model.2 Ginkgolide B also displays neuroprotective effects in various models.3,4 Protects against focal cerebral ischemia via inhibition of the mitochondrial apoptotic pathway.5

References/Citations
1) Foldes-Filep et al. (1987), Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes; Biochem. Biophys. Res. Commun., 148 1412
2) Desquand et al. (1986), Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig; Eur. J. Pharmacol., 127 83
3) Maclennan et al. (2002), The CNS effects of Ginko biloba extracts and ginkgolide B; Prog. Neurobiol., 67 235
4) Li et al. (2013), Neuroprotective effect of ginkogolide B on bupivacaine-induced apoptosis in SH-SY5Y cells; Oxid. Med. Cell. Longev., 2013 159864
5) Wang et al. (2014), Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats; J. Neurosci. Res., 92 232

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Ginkgolide B | 15291-77-7 | Structure | Supplier

Catalog#  10-1080

$40.00
Quantity
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CAS:
15291-77-7
Catalog Number:
10-1080
Activity:
PAF antagonist
Alternate Names:
BN 52021
Chemical Name:
Natural product isolated from Ginko biloba
Molecular Weight:
424.41
Molecular Formula:
C20H24O10
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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