Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts

JNJ-1661010 | FAAH inhibitor

CAS:
681136-29-8
Catalog Number:
10-1298
Activity:
FAAH inhibitor
Alternate Names:
N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
Chemical Name:
4-(3-Phenyl-[1,2,4]thizdiazol-5-yl)-piperazine-1-carboxylic acid phenylamide
Molecular Weight:
365.46
Molecular Formula:
C19H19N5OS
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in vivo. JNJ-1661010 displays analgesic activity in various animal models.

References/Citations:

1) Karbarz et al. (2009), Biochemical and biological properties of 4-(3-phenyl-[1,2,4]thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase; Anesth. Analg., 108 316

JNJ-1661010 | FAAH inhibitor is also available in the Cellular Metabolism Library.
CAS:
681136-29-8
Catalog Number:
10-1298
Activity:
FAAH inhibitor
Alternate Names:
N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide
Chemical Name:
4-(3-Phenyl-[1,2,4]thizdiazol-5-yl)-piperazine-1-carboxylic acid phenylamide
Molecular Weight:
365.46
Molecular Formula:
C19H19N5OS
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Add to Quote

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee