(±) Tranylcypromine hemisulfate | Demethylase inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 50 mg | $40.00 | ||
| 250 mg | $150.00 |
Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4
References/Citations:
1) Knoll et al. (1980), Monoamine oxidase inhibitors: Chemistry and Pharmacology; In, Sandler (ed) Enzyme inhibitors as drugs, MacMillan, London 151
2) Baker et al. (1992), Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine; a review, J.Psychiatry Neurosci. 17 206
3) Lee et al. (2006), Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications; Chemistry and Biology, 13 563
4) Schmidt and McCafferty (2007), trans-2-Phenylcyclopropylamine is a Mechanism-Based Inactivator of the Histone Demethylase LSD1; Biochemistry, 46 4408
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4
References/Citations:
1) Knoll et al. (1980), Monoamine oxidase inhibitors: Chemistry and Pharmacology; In, Sandler (ed) Enzyme inhibitors as drugs, MacMillan, London 151
2) Baker et al. (1992), Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine; a review, J.Psychiatry Neurosci. 17 206
3) Lee et al. (2006), Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications; Chemistry and Biology, 13 563
4) Schmidt and McCafferty (2007), trans-2-Phenylcyclopropylamine is a Mechanism-Based Inactivator of the Histone Demethylase LSD1; Biochemistry, 46 4408
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