1-EBIO | K+ channel activator; Promotes cardiomyocyte differentiation

CAS:
10045-45-1
Catalog Number:
10-3204
Activity:
K+ channel activator; Promotes cardiomyocyte differentiation
Chemical Name:
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one
Alternate Names:
1-Ethylbenzimidazolinone
Molecular Weight:
162.19
Molecular Formula:
C9H10N2O
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml)
Physical Properties:
Crystalline solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
10 mg$40.00
50 mg$148.00

1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays neuroprotective effects in ischemia-induced neuronal cell death3.  Induces embryonic stem cell differentiation into cardiomyocytes and enrichment of pacemaker-like cells.4 Induces production of superoxide and hydrogen peroxide in neutrophils with subsequent apoptosis.5

References/Citations:

1) Adeagbo et al. (1999), 1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol., 379 151
2) Orfila et al. (2014), Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci., 40 3179
3) Allen et al. (2011), SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab., 31 2302
4) Muller et al. (2012), Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev., 8 720
5) Fay et al. (2006), SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA, 103 17548

CAS:
10045-45-1
Catalog Number:
10-3204
Activity:
K+ channel activator; Promotes cardiomyocyte differentiation
Chemical Name:
1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one
Alternate Names:
1-Ethylbenzimidazolinone
Molecular Weight:
162.19
Molecular Formula:
C9H10N2O
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml)
Physical Properties:
Crystalline solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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