10058-F4 | Myc inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $54.00 | ||
| 25 mg | $200.00 |
10058-F4 (403811-55-2) effectively disables c-Myc by inhibiting the c-Myc-Max association and function.1 It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells.2 10058-F4 induces cell cycle arrest, apoptosis and myeloid differentiation in human acute myeloid leukemia.3 Inhibits the MYCN/Max interaction leading to cell cycle arrest, apoptosis and neuronal differentiation in MYCN-amplified neuroblastoma cells.4
References/Citations:
1) Yin et al. (2003), Low molecular weight inhibitors of Myc-Max interaction and function; Oncogene, 22 6151
2) Lin et al. (2007), Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells; Anti-Cancer Drugs, 18161
3) Huang et al. (2006), A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia; Exp. Hematol., 34 1480
4) Zirath et al. (2013), MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells; Proc. Natl. Acad. Sci. USA, 110 10258
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
10058-F4 (403811-55-2) effectively disables c-Myc by inhibiting the c-Myc-Max association and function.1 It prevents the growth of fibroblasts in a c-Myc-dependent manner. Downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells.2 10058-F4 induces cell cycle arrest, apoptosis and myeloid differentiation in human acute myeloid leukemia.3 Inhibits the MYCN/Max interaction leading to cell cycle arrest, apoptosis and neuronal differentiation in MYCN-amplified neuroblastoma cells.4
References/Citations:
1) Yin et al. (2003), Low molecular weight inhibitors of Myc-Max interaction and function; Oncogene, 22 6151
2) Lin et al. (2007), Small-molecule c-Myc inhibitor, 10058-F4, inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells; Anti-Cancer Drugs, 18161
3) Huang et al. (2006), A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia; Exp. Hematol., 34 1480
4) Zirath et al. (2013), MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells; Proc. Natl. Acad. Sci. USA, 110 10258
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