1,10-Phenanthroline HCl | Zn metalloprotease inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 gram | $20.00 | ||
| 5 gram | $40.00 |
1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1 It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+. It may be used when preparing cell lysates for enrichment of ubiquitinated proteins which are especially sensitive to DUBs in the JAMM family.2,3
References/Citations:
1) Swann et al (1981) Zinc metalloenzyme properties of active and latent collagenase from rabbit bone;. Biochem.J., 195 41
2) Cooper et al. (2009) K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1; EMBO J., 28 621
3) Lu et al. (2015) Substrate degradation by the proteasome: A single-molecule kinetic analysis; Science, 348 200
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
1,10-Phenanthroline (18851-33-7) is a high affinity chelator of divalent metal ions and may be used to inhibit zinc metalloenzymes.1 It is a potent inhibitor of JAMM-type isopeptidases (DUBs) acting via chelation of an active site Zn2+. It may be used when preparing cell lysates for enrichment of ubiquitinated proteins which are especially sensitive to DUBs in the JAMM family.2,3
References/Citations:
1) Swann et al (1981) Zinc metalloenzyme properties of active and latent collagenase from rabbit bone;. Biochem.J., 195 41
2) Cooper et al. (2009) K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1; EMBO J., 28 621
3) Lu et al. (2015) Substrate degradation by the proteasome: A single-molecule kinetic analysis; Science, 348 200
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1-855-FOCUS21
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