1400W | iNOS inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $40.00 | ||
| 25 mg | $145.00 |
1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3 (Ki = 7 nM) over nNOS or eNOS (Ki‘s of 2 μM and 50 μM respectively).1 1400W is cell permeable and active in vivo.2
References/Citations
1) Garvey et al. (1997), 1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem., 272 4959
2) Thomsen et al. (1997), Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res., 57 3300
3) Pigott et al. (2013), On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol., 168 1255
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3 (Ki = 7 nM) over nNOS or eNOS (Ki‘s of 2 μM and 50 μM respectively).1 1400W is cell permeable and active in vivo.2
References/Citations
1) Garvey et al. (1997), 1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem., 272 4959
2) Thomsen et al. (1997), Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res., 57 3300
3) Pigott et al. (2013), On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol., 168 1255
Related products
-
Sorafenib | Multi-kinase inhibitor
From $40.00CAS:284461-73-0Catalog Number:10-2174Activity:Inhibitor of Raf-1 and other kinasesAlternate Names:BAY 43-9006Chemical Name:4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamideMolecular Weight:464.83Molecular Formula:C21H16ClF3N4O3Solubility:Soluble in DMSO (up to 200 mg/ml) or in Ethanol (up to 3 mg/ml).Physical Properties:Off-white solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
P5091 | DUB USP7 inhibitor
From $60.00CAS:882257-11-6Catalog Number:10-1422Activity:DUB USP7 inhibitorChemical Name:1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanoneMolecular Weight:348.23Molecular Formula:C12H7Cl2NO3S2Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 40 mg/ml with warming).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
Indirubin-3′-monoxime | GSK-3ß and CDK inhibitor
From $60.00CAS:160807-49-8Catalog Number:10-1488Activity:GSK-3β and CDK inhibitorAlternate Names:Indirubin-3’oximeChemical Name:3-[1,3-Dihydro-3-(hydroxyimino-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-oneMolecular Weight:277.29Molecular Formula:C16H11N3O2Solubility:Soluble in DMSO (up to 6 mg/ml) or in Ethanol (up to 4 mg/ml).Physical Properties:Dark red or brown solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
