17-AHA-Geldanamycin | Geldanamycin affinity chromatography ligand
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $100.00 | ||
| 25 mg | $400.00 |
17-AHA-geldanamycin is a semi-synthetic analog of geldanamycin containing a linker bearing a free NH2 functional group for conjugation. Selectively binds to HSP90 and may be used to prepare geldanamycin beads and affinity columns for purification of HSP90 and associated client proteins.1,2 Has been used in a copolymeric composition for geldanamycin sustained delivery and controlled release3,4 as well as other applications.
References/Citations:
1) Xie et al. (2005), Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion; Oncogene, 24 3697
2) Marcu et al. (2000), Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins; J. Natl. Cancer Inst., 92 242
3) Borgman et al. (2009), Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery; Mol. Pharmacol. 6 1836
4) Kasuya et al. (2001), Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates; J. Control. Release, 74 203
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
17-AHA-geldanamycin is a semi-synthetic analog of geldanamycin containing a linker bearing a free NH2 functional group for conjugation. Selectively binds to HSP90 and may be used to prepare geldanamycin beads and affinity columns for purification of HSP90 and associated client proteins.1,2 Has been used in a copolymeric composition for geldanamycin sustained delivery and controlled release3,4 as well as other applications.
References/Citations:
1) Xie et al. (2005), Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion; Oncogene, 24 3697
2) Marcu et al. (2000), Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins; J. Natl. Cancer Inst., 92 242
3) Borgman et al. (2009), Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery; Mol. Pharmacol. 6 1836
4) Kasuya et al. (2001), Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates; J. Control. Release, 74 203
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