17-PAAG | Propargyl geldanamycin click reagent
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 2 mg | $55.00 | ||
| 5 mg | $130.00 |
17-PAAG is a semi-synthetic analog of geldanamycin which possesses an acetylenic side chain for coupling to other probes, fluorophores and bioactive molecules such as steroids via click chemistry.1 Chemical modifications at C17 are well known not to interfere with binding of geldanamycin to HSP90 client proteins.2-4
References/Citations:
1) Hendricks et al. (2013), Synthesis and preliminary evaluation steroidal anti-estrogen-geldanamycin conjugates; Bioorg. Med. Chem. Lett., 23 3635
2) Llauger-Bufi et al. (2003), Synthesis of novel fluorescent probes for the molecular chaperone Hsp90; Bioorg. Med. Chem. Lett., 13 3975
3) Kim et al. (2004), Development of a fluorescence polarization assay for the molecular chaperone Hsp90; J. Biomol. Screen., 9 375
4) Austin et al. (2012), Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors; J. Biomol. Screen, 17 868
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
17-PAAG is a semi-synthetic analog of geldanamycin which possesses an acetylenic side chain for coupling to other probes, fluorophores and bioactive molecules such as steroids via click chemistry.1 Chemical modifications at C17 are well known not to interfere with binding of geldanamycin to HSP90 client proteins.2-4
References/Citations:
1) Hendricks et al. (2013), Synthesis and preliminary evaluation steroidal anti-estrogen-geldanamycin conjugates; Bioorg. Med. Chem. Lett., 23 3635
2) Llauger-Bufi et al. (2003), Synthesis of novel fluorescent probes for the molecular chaperone Hsp90; Bioorg. Med. Chem. Lett., 13 3975
3) Kim et al. (2004), Development of a fluorescence polarization assay for the molecular chaperone Hsp90; J. Biomol. Screen., 9 375
4) Austin et al. (2012), Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors; J. Biomol. Screen, 17 868
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