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2'-Deoxy-5-fluorocytidine | Irreversible DNA methyl transferase inhibitor

2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5'-Azacytidine (Cat.# 10-1267) and decitabine (Cat.# 10-2412), 2-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation2. It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways3. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo4.

References/Citations
1) Ren et al. (2011), DNA hypermethylation as a chemotherapy target; Cell Signal, 23 1082
2) Gowher et al. (2004), Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy; Cancer Biol. Ther., 3 1062
3) Zhao et al. (2002), Inhibition of cancer cell proliferation by 5-fluoro-2'-deoxycytidine, a DNA methylation inhibitor, through activation of DNA damage response pathway; Springerplus, 1 65
4) Kumaki et al. (2001), In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections; Antiviral Res., 92 329

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Focus Biomolecules chemical structure 2'-Deoxy-5-fluorocytidine | DNA methyl transferase inhibitor | CAS 10356-76-0

Catalog#  10-2685

$52.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
10356-76-0
Catalog Number:
10-2685
Activity:
Irreversible DNA methyl transferase inhibitor
Alternate Names:
FCDR; NSC-48006; FdCyd
Chemical Name:
5-Fluoro-2'deoxycytidine
Molecular Weight:
245.21
Molecular Formula:
C9H12FN3O4
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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