25-Hydroxycholesterol | Biologically active cholesterol metabolite
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $30.00 | ||
| 25 mg | $105.00 |
25-Hydroxycholesterol (2140-46-7) is a metabolite resulting from the action of cholesterol 25-hydroxylase on cholesterol. However, since cholesterol 25-hydroxylase knock-out mice still have significant levels of 25-hydroxycholesterol there must be alternate pathways of generation that have yet to be determined.1 Likewise, the biological role of 25-hydroxycholesterol remains somewhat unclear. 25-Hydroxycholesterol is frequently mentioned as an important regulator of cholesterol metabolism, but apparently normal cholesterol regulation in organisms with both high and low levels of the compound make this association unclear. More recent reports have linked 25 hydroxycholesterol and one of it’s metabolites to immunoregulatory roles2, but more information is needed before it is clear if that is indeed a primary role for the compound.
References/Citations:
1) Diczialusy (2013), On the formation and possible biological role of 25-hydroxcholesterol; Biochimie, 95 455
2) McDonald and Russell (2010), 25-hydroxycholesterol: a new life in immunology: J. Leuko. Biol. 88 1071
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
25-Hydroxycholesterol (2140-46-7) is a metabolite resulting from the action of cholesterol 25-hydroxylase on cholesterol. However, since cholesterol 25-hydroxylase knock-out mice still have significant levels of 25-hydroxycholesterol there must be alternate pathways of generation that have yet to be determined.1 Likewise, the biological role of 25-hydroxycholesterol remains somewhat unclear. 25-Hydroxycholesterol is frequently mentioned as an important regulator of cholesterol metabolism, but apparently normal cholesterol regulation in organisms with both high and low levels of the compound make this association unclear. More recent reports have linked 25 hydroxycholesterol and one of it’s metabolites to immunoregulatory roles2, but more information is needed before it is clear if that is indeed a primary role for the compound.
References/Citations:
1) Diczialusy (2013), On the formation and possible biological role of 25-hydroxcholesterol; Biochimie, 95 455
2) McDonald and Russell (2010), 25-hydroxycholesterol: a new life in immunology: J. Leuko. Biol. 88 1071
Related products
-
MK-886 | FLAP inhibitor
From $70.00CAS:118414-82-7Catalog Number:10-1040Activity:FLAP inhibitorAlternate Names:L-663,536Chemical Name:3-[1-(4-Chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acidMolecular Weight:472.08Molecular Formula:C27H34ClNO2SSolubility:Soluble in DMSO (up to 40 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
Retinoic acid | Retinoid RAR agonist
From $30.00CAS:302-79-4Catalog Number:10-1138Activity:Retinoid RAR agonistAlternate Names:ATRAChemical Name:3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E,-nonatetraenoic acidMolecular Weight:300.44Molecular Formula:C20H28O2Solubility:Soluble in DMSO (up to 8 mg/ml) or in Ethanol (up to 15 mg/ml).Physical Properties:Yellow solidPurity:98%
NMR (Conforms)Storage Temperature:-20°C (des.)Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
Ginkgolide B | PAF receptor antagonist
From $40.00CAS:15291-77-7Catalog Number:10-1080Activity:PAF antagonistAlternate Names:BN 52021Chemical Name:Natural product isolated from Ginko bilobaMolecular Weight:424.41Molecular Formula:C20H24O10Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 monthsShipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
20% OFF
For Postdoc
Customers!
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.