2E151 | Vaccine co-adjuvant

CAS:
 2416963-37-4
Catalog Number:
 10-4145

Available Options

SizePriceQuantity 
10mg$85.00
50mg$325.00

Vaccine adjuvants are materials that enhance the magnitude and duration of protective immune responses, typically via pattern recognition receptors (PRR).  2E151 (2416963-37-4) is a co-adjuvant that increases the potency of toll-like receptor (TLR) adjuvants and overall enhances T cell stimulation/proliferation and cytokine production.1 Its increases intracellular Ca2+ via extracellular Ca2+ influx, leading to NF-kB activation (EC50 = 0.9 µM)2 via IKK/MAPK phosphorylation and NFAT translocation in B cells and monocytes.

References/Citations:

  1. Saito, et al. (2022), Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity; ACS Chem. Biol., 17 217
  2. Shukla, et al. (2021), Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-kB activation; Bioorg. Med. Chem., 43 116242
CAS:
2416963-37-4
Catalog Number:
10-4145
Activity:
Vaccine co-adjuvant
Chemical Names:
N-[4-(2,5-Dimethylphenyl)-1,3-thiazol-2-yl]-4-(4-propylpiperidin-1-yl)sulfonylbenzamide
Molecular Weight:
497.67
Molecular Formula:

C26H31N3O3S2

Solubility:
Soluble in DMSO (at least 50 mg/ml)
Physical Properties:
White solid
Purity:

98% HPLC
NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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