2E151 | Vaccine co-adjuvant
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 10mg | $85.00 | ||
| 50mg | $325.00 |
Vaccine adjuvants are materials that enhance the magnitude and duration of protective immune responses, typically via pattern recognition receptors (PRR). 2E151 (2416963-37-4) is a co-adjuvant that increases the potency of toll-like receptor (TLR) adjuvants and overall enhances T cell stimulation/proliferation and cytokine production.1 Its increases intracellular Ca2+ via extracellular Ca2+ influx, leading to NF-kB activation (EC50 = 0.9 µM)2 via IKK/MAPK phosphorylation and NFAT translocation in B cells and monocytes.
References/Citations:
- Saito, et al. (2022), Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity; ACS Chem. Biol., 17 217
- Shukla, et al. (2021), Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-kB activation; Bioorg. Med. Chem., 43 116242
C26H31N3O3S2
98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Vaccine adjuvants are materials that enhance the magnitude and duration of protective immune responses, typically via pattern recognition receptors (PRR). 2E151 (2416963-37-4) is a co-adjuvant that increases the potency of toll-like receptor (TLR) adjuvants and overall enhances T cell stimulation/proliferation and cytokine production.1 Its increases intracellular Ca2+ via extracellular Ca2+ influx, leading to NF-kB activation (EC50 = 0.9 µM)2 via IKK/MAPK phosphorylation and NFAT translocation in B cells and monocytes.
References/Citations:
- Saito, et al. (2022), Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity; ACS Chem. Biol., 17 217
- Shukla, et al. (2021), Structure-activity relationship studies in substituted sulfamoyl benzamidothiazoles that prolong NF-kB activation; Bioorg. Med. Chem., 43 116242
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