2GBI | Hv1 channel blocker
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 50 mg | $50.00 | ||
| 250 mg | $100.00 |
2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3 Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4
References/Citations:
1) Hong et al. (2015), Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep., 5 14077
2) Hong et al. (2014), Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA, 111 9971
3) Gianti et al. (2016), On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA, 113 E8359
4) Pupo and Gonzalez (2014), In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA, 111 9673
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3 Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4
References/Citations:
1) Hong et al. (2015), Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep., 5 14077
2) Hong et al. (2014), Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA, 111 9971
3) Gianti et al. (2016), On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA, 113 E8359
4) Pupo and Gonzalez (2014), In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA, 111 9673
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