Size : | Price | Quantity | |
---|---|---|---|
50 mg | $50.00 | ||
250 mg | $100.00 |
2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3 Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4
References/Citations:
1) Hong et al. (2015), Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep., 5 14077
2) Hong et al. (2014), Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA, 111 9971
3) Gianti et al. (2016), On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA, 113 E8359
4) Pupo and Gonzalez (2014), In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA, 111 9673
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2GBI (5418-95-1) is a selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3 Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4
References/Citations:
1) Hong et al. (2015), Interrogation of the intersubunit interface if the open Hv1 proton channel with a probe of allosteric coupling; Sci. Rep., 5 14077
2) Hong et al. (2014), Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives; Proc. Natl. Acad. Sci. USA, 111 9971
3) Gianti et al. (2016), On the role of water density fluctuations in the inhibition of a proton channel; Proc. Natl. Acad. Sci. USA, 113 E8359
4) Pupo and Gonzalez (2014), In pursuit of an inhibitory drug for the proton channel; Proc. Natl. Acad. Sci. USA, 111 9673
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