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3-Methyladenine | Autophagosome inhibitor

3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and hydroxyphenazine-induced toxicity3. 3-Methyladenine enhances induction of apoptosis by celastrol (Cat.# 10-2187) in human pancreatic cancer cells4.

References/Citations
1) Seglen and Gordon et al. (1982), 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes; Proc. Natl. Acad. Sci. USA, 79 1889
2) Blommaart et al. (1997), The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem., 243 240
3) McFarland et al. (2012), Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity; Arch. Toxicol., 86 275
4) Zhao et al. (2014), Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models; Curr. Mol. Med., 14 555

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Focus Biomolecules cell signaling supplier, chemical structure of 3-Methyladenine | Autophagosome inhibitor | CAS 5142-23-4

Catalog#  10-2686

$30.00
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CAS:
5142-23-4
Catalog Number:
10-2686
Activity:
Autophagosome inhibitor
Alternate Names:
3-MA
Chemical Name:
3-Methyl-3H-purin-6-amine
Molecular Weight:
149.15
Molecular Formula:
C6H7N5
Solubility:
Soluble in DMSO (up to 3 mg/ml), or in DMF (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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