4-Octyl itaconate | Nrf2 activator
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $50.00 | ||
| 100 mg | $150.00 |
4-Octyl itaconate (3133-16-2) is a cell-permeable analog of itaconic acid which activates the anti-inflammatory transcription factor Nrf2 via alkylation of KEAP1.1 It inhibits various forms of cell death including ferroptosis2 and gasdermin B-mediated pyroptosis3 while inducing secretion of anti-inflammatory proteins4 and promoting a wound-resolving phenotype in pro-inflammatory macrophages5.
References/Citations:
- Mills et al. (2018), Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1; Nature, 556 113
- Pan et al. (2024), 4-Octyl itaconate protects chondrocytes against IL-1β-induced oxidative stress and ferroptosis by inhibiting GPX4 methylation in osteoarthritis; Int. Immunopharmacol., 137 112531
- Gong et al. (2024), 4-Octyl itaconate blocks GSDMB-mediated pyroptosis and restricts inflammation by inactivating granzyme A; Cell Prolif., 57 e13711
- Diskin et al. (2023), 4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2; IJ. mmunol., 211 1032
- Maassen et al. (2023), Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages; Redox. Biol., 59 102591
C13H22O4
>98% TLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
4-Octyl itaconate (3133-16-2) is a cell-permeable analog of itaconic acid which activates the anti-inflammatory transcription factor Nrf2 via alkylation of KEAP1.1 It inhibits various forms of cell death including ferroptosis2 and gasdermin B-mediated pyroptosis3 while inducing secretion of anti-inflammatory proteins4 and promoting a wound-resolving phenotype in pro-inflammatory macrophages5.
References/Citations:
- Mills et al. (2018), Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1; Nature, 556 113
- Pan et al. (2024), 4-Octyl itaconate protects chondrocytes against IL-1β-induced oxidative stress and ferroptosis by inhibiting GPX4 methylation in osteoarthritis; Int. Immunopharmacol., 137 112531
- Gong et al. (2024), 4-Octyl itaconate blocks GSDMB-mediated pyroptosis and restricts inflammation by inactivating granzyme A; Cell Prolif., 57 e13711
- Diskin et al. (2023), 4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2; IJ. mmunol., 211 1032
- Maassen et al. (2023), Itaconate promotes a wound resolving phenotype in pro-inflammatory macrophages; Redox. Biol., 59 102591
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