4,9-Anhydrotetrodotoxin | Selective sodium channel blocker
NMR (Conforms)
High Res. Mass (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 µg | $125.00 | ||
| 1 mg | $995.00 |
4,9-Anhydrotetrodotoxin (13072-89-4) is a highly selective blocker of the Na(v1.6) sodium channel. (IC50‘s: Na(v1.2) = 260 nM, Na(v1.3) = 341 nM, Na(v1.4) = 988 nM, Na(v1.5) = 11.6 μM, Na(v1.6) = 7.8 nM, Na(v1.7) = 1.27 μM, Na(v1.8) = >30 μM.).1 It has recently been shown to also potently block human Nav1.1 channels.2
References/Citations:
1) Rosker et al. (2007), The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel; Am.J.Physiol.Cell Physiol., 293 C783.
2) Denomme et al. (2020), The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6; Neurosci. Lett. 724 134853
NMR (Conforms)
High Res. Mass (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
4,9-Anhydrotetrodotoxin (13072-89-4) is a highly selective blocker of the Na(v1.6) sodium channel. (IC50‘s: Na(v1.2) = 260 nM, Na(v1.3) = 341 nM, Na(v1.4) = 988 nM, Na(v1.5) = 11.6 μM, Na(v1.6) = 7.8 nM, Na(v1.7) = 1.27 μM, Na(v1.8) = >30 μM.).1 It has recently been shown to also potently block human Nav1.1 channels.2
References/Citations:
1) Rosker et al. (2007), The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel; Am.J.Physiol.Cell Physiol., 293 C783.
2) Denomme et al. (2020), The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6; Neurosci. Lett. 724 134853
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