5alpha,6alpha-Epoxycholesterol | LXR ligand
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 25 mg | $25.00 | ||
| 100 mg | $85.00 |
5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol. It is a major oxysterol found in processed food1 and has been implicated in atherosclerosis2,3. 5α,6α-Epoxycholesterol has been found to be an endogenous ligand for LXR (EC50 = 76 nM).4
References/Citations:
1) Leonarduzzi et al. (2002), Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effect (review); J. Nutr. Biochem., 13 700
2) Björkhem et al. (1988), Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia; J. Lipid Res., 29 1031
3) Staprans et al. (2005), The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis; Mol. Nutr. Food Res., 49 1075
4) Berrodin et al. (2010), Identification of 5α,6α-Epoxycholesterol as a novel modulator of Liver X Receptor; Mol. Pharmacol., 78 1046
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol. It is a major oxysterol found in processed food1 and has been implicated in atherosclerosis2,3. 5α,6α-Epoxycholesterol has been found to be an endogenous ligand for LXR (EC50 = 76 nM).4
References/Citations:
1) Leonarduzzi et al. (2002), Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effect (review); J. Nutr. Biochem., 13 700
2) Björkhem et al. (1988), Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia; J. Lipid Res., 29 1031
3) Staprans et al. (2005), The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis; Mol. Nutr. Food Res., 49 1075
4) Berrodin et al. (2010), Identification of 5α,6α-Epoxycholesterol as a novel modulator of Liver X Receptor; Mol. Pharmacol., 78 1046
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1-855-FOCUS21
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