5alpha,6alpha-Epoxycholesterol | LXR ligand
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 25 mg | $25.00 | ||
| 100 mg | $85.00 |
5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol. It is a major oxysterol found in processed food1 and has been implicated in atherosclerosis2,3. 5α,6α-Epoxycholesterol has been found to be an endogenous ligand for LXR (EC50 = 76 nM).4
References/Citations:
1) Leonarduzzi et al. (2002), Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effect (review); J. Nutr. Biochem., 13 700
2) Björkhem et al. (1988), Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia; J. Lipid Res., 29 1031
3) Staprans et al. (2005), The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis; Mol. Nutr. Food Res., 49 1075
4) Berrodin et al. (2010), Identification of 5α,6α-Epoxycholesterol as a novel modulator of Liver X Receptor; Mol. Pharmacol., 78 1046
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol. It is a major oxysterol found in processed food1 and has been implicated in atherosclerosis2,3. 5α,6α-Epoxycholesterol has been found to be an endogenous ligand for LXR (EC50 = 76 nM).4
References/Citations:
1) Leonarduzzi et al. (2002), Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effect (review); J. Nutr. Biochem., 13 700
2) Björkhem et al. (1988), Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia; J. Lipid Res., 29 1031
3) Staprans et al. (2005), The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis; Mol. Nutr. Food Res., 49 1075
4) Berrodin et al. (2010), Identification of 5α,6α-Epoxycholesterol as a novel modulator of Liver X Receptor; Mol. Pharmacol., 78 1046
Related products
-
RHC-80267 | DAG Lipase inhibitor
From $55.00CAS:83654-05-1Catalog Number:10-1051Activity:DAG Lipase inhibitorAlternate Names:U-57908Chemical Name:1,6-bis(Cyclohexyloximinocarbonyl-amino)hexaneMolecular Weight:394.53Molecular Formula:C20H34N4O4Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Off-white solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 monthsShipping Code:RT -
NA-Gly | GPR18 agonist
From $60.00CAS:179113-91-8Catalog Number:10-1200Activity:GPR18 agonistAlternate Names:N-ArachidonylglycineChemical Name:N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)glycineMolecular Weight:361.53Molecular Formula:C22H35NO3Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Beige waxy solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Product is subject to oxidation. Solutions in degassed DMSO may be stored at -20°C for up to 1 month.Shipping Code:Blue Ice -
Zileuton | 5-LO inhibitor
From $32.00CAS:111406-87-2Catalog Number:10-1098Activity:5-LO inhibitorChemical Name:N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyureaMolecular Weight:236.29Molecular Formula:C11H12N2O2SSolubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:>98%
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
20% OFF
For Postdoc
Customers!
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.