(5Z)-7-Oxozeaenol | TAK1 inhibitor
CAS:
253863-19-3
Catalog Number:
10-3023
Activity:
TAK1 inhibitor
Chemical Names:
(3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
Alternate Name:
LL-Z-1640-2
Molecular Weight:
362.38
Molecular Formula:
C19H22O7
Solubility:
Soluble in DMSO (9 mg/ml); ethanol (3 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 mg | $90.00 | ||
| 5 mg | $380.00 |
(5Z)-7-Oxozeaenol (253863-19-3) is a potent and selective inhibitor of TAK1 (mitogen activated protein kinase kinase kinase) IC50 = 8 nM.1 Selective over MEKK1 and MEKK4. Blocks IL-1-induced activation of TAK1 in cell culture.1 Blocks the production of pro-inflammatory cytokines and displays anti-inflammatory activity in various models.2-4
References/Citations:
- Ninomiya-Tsuji et al. (2003), A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase; J. Biol. Chem., 278 18485
- Windheim et al. (2007), Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide; Biochem. J., 404 179
- Xu et al. (2016), Blockade of TGF-ß-activated kinase 1 prevents advanced glycation end products-induced inflammatory response in macrophages; Cytokine, 78 62
- Ivshina et al. (2015), CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response; Mol. Cell. Biol., 35 610
CAS:
253863-19-3
Catalog Number:
10-3023
Activity:
TAK1 inhibitor
Chemical Names:
(3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
Alternate Name:
LL-Z-1640-2
Molecular Weight:
362.38
Molecular Formula:
C19H22O7
Solubility:
Soluble in DMSO (9 mg/ml); ethanol (3 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
(5Z)-7-Oxozeaenol (253863-19-3) is a potent and selective inhibitor of TAK1 (mitogen activated protein kinase kinase kinase) IC50 = 8 nM.1 Selective over MEKK1 and MEKK4. Blocks IL-1-induced activation of TAK1 in cell culture.1 Blocks the production of pro-inflammatory cytokines and displays anti-inflammatory activity in various models.2-4
References/Citations:
- Ninomiya-Tsuji et al. (2003), A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase; J. Biol. Chem., 278 18485
- Windheim et al. (2007), Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide; Biochem. J., 404 179
- Xu et al. (2016), Blockade of TGF-ß-activated kinase 1 prevents advanced glycation end products-induced inflammatory response in macrophages; Cytokine, 78 62
- Ivshina et al. (2015), CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response; Mol. Cell. Biol., 35 610
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