6-Mercaptopurine | Purine antimetabolite and immunomodulator
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 g | $40.00 | ||
| 200 mg | $25.00 |
6-Mercaptopurine (6112-76-1) ) is a purine antimetabolite drug used to treat acute lymphocytic leukemia, Crohn’s disease, ulcerative colitis, and inflammatory bowel disease.1 It inhibits DNA synthesis by inhibiting the production of purine containing nucleotides. The immunomodulatory activity of 6-Mercaptopurine is mainly the result of the 6-MP metabolite 6-thioguanine triphosphate (6-TGTP) binding to small GTPase Rac1.2
References/Citations:
- Sahasranaman et al. (20088), Clinical pharmacology and pharmacogenetics of thiopurines; Eur. J. Clin. Pharmacol., 64 753
- De Boer et al. (2018), Thiopurines in Inflammatory Bowel Disease: New Findings and Perspectives; J. Crohns Colitis., 12 610
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
6-Mercaptopurine (6112-76-1) ) is a purine antimetabolite drug used to treat acute lymphocytic leukemia, Crohn’s disease, ulcerative colitis, and inflammatory bowel disease.1 It inhibits DNA synthesis by inhibiting the production of purine containing nucleotides. The immunomodulatory activity of 6-Mercaptopurine is mainly the result of the 6-MP metabolite 6-thioguanine triphosphate (6-TGTP) binding to small GTPase Rac1.2
References/Citations:
- Sahasranaman et al. (20088), Clinical pharmacology and pharmacogenetics of thiopurines; Eur. J. Clin. Pharmacol., 64 753
- De Boer et al. (2018), Thiopurines in Inflammatory Bowel Disease: New Findings and Perspectives; J. Crohns Colitis., 12 610
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1-855-FOCUS21
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