6BIO | GSK-3 inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $65.00 | ||
| 25 mg | $260.00 |
6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.2 Promotes proliferation in mammalian cardiomyocytes.2 6BIO is a potent inhibitor of malignant lymphoid cell proliferation.3
References/Citations:
1) Meijer et al. (2003), GSK-3-selective inhibitors derived from Tyrian purple indirubins; Chem. Biol., 10 1255
2) Tseng et al. (2006), The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes; Chem. Biol., 13 957
3) Chebel et al. (2009), Indirubin derivatives inhibit malignant lymphoid cell proliferation; Leuk. Lymphoma, 50 2049
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells.2 Promotes proliferation in mammalian cardiomyocytes.2 6BIO is a potent inhibitor of malignant lymphoid cell proliferation.3
References/Citations:
1) Meijer et al. (2003), GSK-3-selective inhibitors derived from Tyrian purple indirubins; Chem. Biol., 10 1255
2) Tseng et al. (2006), The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes; Chem. Biol., 13 957
3) Chebel et al. (2009), Indirubin derivatives inhibit malignant lymphoid cell proliferation; Leuk. Lymphoma, 50 2049
Related products
-
Simvastatin | HMG-CoA reductase inhibitor
From $50.00CAS:79902-63-9Catalog Number:10-1018Activity:HMG-CoA reductase inhibitorAlternate Names:MevinolinChemical Name:2,2-Dimethyl-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acidMolecular Weight:418.58Molecular Formula:C25H38O5Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.Shipping Code:RT -
KB-R7943 mesylate | NCX inhibitor
From $65.00CAS:182004-65-5Catalog Number:10-1163Activity:TRPC channel blockerChemical Name:2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylateMolecular Weight:427.49Molecular Formula:C16H17N3O3S CH3SO3HSolubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Tan solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Phenoxybenzamine HCl | Calmodulin antagonist
From $30.00CAS:63-92-3Catalog Number:10-1237Activity:Calmodulin antagonistChemical Name:N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochlorideMolecular Weight:340.29Molecular Formula:C18H22ClNO HClSolubility:Soluble in DMSO (up to 50 mg/ml), or in Water (up to 15 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
