8-pCPT-2-O-Me-cAMP-AM | Epac activator
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 100 µg | $148.00 |
8-pCPT-2-O-Me-cAMP-AM (1152197-23-3) is a potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator.1 Induces RAP1 activation and insulin secretion in pancreatic beta cell lines.2-5 Induces vascular relaxation in rat mesenteric artery.6 The acetoxymethyl ester confers increased cell-permeability and is cleaved by endogenous esterases to yield the active compound, 8-pCPT-2′-O-Me-cAMP. Addition to cell cultures should be done in serum-free media as esterases in serum will cleave the acetoxymethyl ester and reduce cell permeability.
References/Citations:
1) Vliem et al. (2008), 8-pCPT-2′-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue; Chem. Biochem., 9 2052
2) Chepurny et al. (2009), Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2′-O-Me-cAMP-AM; J. Biol. Chem., 284 10728
3) Kelley et al. (2009), Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM; Islets, 1 260
4) Chepurny et al. (2010), PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM in human islets of Langerhans; Am. J. Physiol. Endocrinol. Metab., 298 E622
5) Dzhura et al. (2011), Phospholipase C-ε links EPAC2 activation to the potentiation of glucose stimulated insulin secretion from mouse islets of Langerhans; Islets, 3 121
6) Roberts et al. (2013), Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+-sensitive K+ channels in rat mesenteric artery; J. Physiol., 591 5107
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
8-pCPT-2-O-Me-cAMP-AM (1152197-23-3) is a potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator.1 Induces RAP1 activation and insulin secretion in pancreatic beta cell lines.2-5 Induces vascular relaxation in rat mesenteric artery.6 The acetoxymethyl ester confers increased cell-permeability and is cleaved by endogenous esterases to yield the active compound, 8-pCPT-2′-O-Me-cAMP. Addition to cell cultures should be done in serum-free media as esterases in serum will cleave the acetoxymethyl ester and reduce cell permeability.
References/Citations:
1) Vliem et al. (2008), 8-pCPT-2′-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue; Chem. Biochem., 9 2052
2) Chepurny et al. (2009), Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2′-O-Me-cAMP-AM; J. Biol. Chem., 284 10728
3) Kelley et al. (2009), Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM; Islets, 1 260
4) Chepurny et al. (2010), PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM in human islets of Langerhans; Am. J. Physiol. Endocrinol. Metab., 298 E622
5) Dzhura et al. (2011), Phospholipase C-ε links EPAC2 activation to the potentiation of glucose stimulated insulin secretion from mouse islets of Langerhans; Islets, 3 121
6) Roberts et al. (2013), Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+-sensitive K+ channels in rat mesenteric artery; J. Physiol., 591 5107
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