A-803467 | NaV1.8 blocker

CAS:
944261-79-4
Catalog Number:
10-1066
Activity:
NaV1.8 blocker
Chemical Name:
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
Molecular Weight:
357.8
Molecular Formula:
C19H16ClNO4
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
10 mg$50.00
50 mg$200.00
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A-803467 (944261-79-4) is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and neuropathic pain in a variety of animal models. IC50‘s for rat and human Nav1.8 are 140 nM and 8.0 nM respectively.

References/Citations:

1) Jarvis et al. (2007), A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat; Proc. Natl. Acad. Sci. USA, 104 8520
2) McGaraughty et al. (2008), A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats; J. Pharmacol. Exp. Ther., 324 1204

CAS:
944261-79-4
Catalog Number:
10-1066
Activity:
NaV1.8 blocker
Chemical Name:
5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
Molecular Weight:
357.8
Molecular Formula:
C19H16ClNO4
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 2 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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