NEWS & EVENTS

A potential new role for RIP1 kinase

by | Aug 24, 2020 | Focus New

Researchers have discovered that inhibition of RIP1 kinase blocks the progression of multiple sclerosis in an immune-induced demyelination mouse model (EAE) but not a chemically-induced one (CPZ). RIPA-56 (Focus Biomolecules Cat# 10-4611) blocked disease progression at a step of monocyte elevation downstream of T-cell activation and myelin-specific antibody generation but upstream of blood-brain barrier breakdown. This represents a previously unknown function of RIP1 kinase and offers a potential new therapeutic opportunity for treatment of immune system mediated demyelinating diseases such as multiple sclerosis.

10.1073/pnas.1819917116

Stay Connected

Home >> A potential new role for RIP1 kinase

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

®Copyright 2021 Focus Biomolecules. All Rights Reserved. Site by A.N. Creative