A1899 | Potent and Selective K2P3.1 blocker
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $245.00 |
A1899 (498577-46-1) is a potent and selective blocker of the two-pore domain potassium channels K2P3.1 (TASK-1; IC50 = 7 nM) and K2P9.1 (TASK-3; IC50 = 70 nM).1 It stimulated breathing in isoflurane-anesthetized rats.2
References/Citations:
- Streit et al. (2011), A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the the TASK-1 Open Pore; J. Biol. Chem. 286 13977
- Choski et al. (2015), Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore; Mol. Pharmacol. 88 926
C30H26F2N2O3
>97% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
A1899 (498577-46-1) is a potent and selective blocker of the two-pore domain potassium channels K2P3.1 (TASK-1; IC50 = 7 nM) and K2P9.1 (TASK-3; IC50 = 70 nM).1 It stimulated breathing in isoflurane-anesthetized rats.2
References/Citations:
- Streit et al. (2011), A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the the TASK-1 Open Pore; J. Biol. Chem. 286 13977
- Choski et al. (2015), Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore; Mol. Pharmacol. 88 926
Related products
-
DO264 | ABHD12 inhibitor
From $70.00CAS:2301866-59-9Catalog Number:10-3712Activity:ABHD12 inhibitorChemical Name:1-(1-(3-Chloro-4-(2-chloro-4-(trifluoromethyl)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thioureaMolecular Weight:542.40Molecular Formula:C23H20Cl2F3N5OSSolubility:Soluble in DMSO (up to 30 mg/ml).Physical Properties:Pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
Levetiracetam | Anticonvulsant
From $45.00CAS:102767-28-2Catalog Number:10-2040Activity:AnticonvulsantChemical Name:2(S)-(2-Oxopyrrolidin-1-yl)butyramideMolecular Weight:170.21Molecular Formula:C29H14N2O2Solubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:White solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
HPI-1 | Hedgehog pathway inhibitor
From $75.00CAS:599150-20-6 (anhydrous)Catalog Number:10-4522Activity:Hedgehog pathway inhibitorChemical Name:2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylateMolecular Weight:463.52 (anhydrous)Molecular Formula:C27H29NO6 xH20Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Yellow solidPurity:>98% by TLC
NMR (conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
