A1899 | Potent and Selective K2P3.1 blocker
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $245.00 |
A1899 (498577-46-1) is a potent and selective blocker of the two-pore domain potassium channels K2P3.1 (TASK-1; IC50 = 7 nM) and K2P9.1 (TASK-3; IC50 = 70 nM).1 It stimulated breathing in isoflurane-anesthetized rats.2
References/Citations:
- Streit et al. (2011), A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the the TASK-1 Open Pore; J. Biol. Chem. 286 13977
- Choski et al. (2015), Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore; Mol. Pharmacol. 88 926
C30H26F2N2O3
>97% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
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A1899 (498577-46-1) is a potent and selective blocker of the two-pore domain potassium channels K2P3.1 (TASK-1; IC50 = 7 nM) and K2P9.1 (TASK-3; IC50 = 70 nM).1 It stimulated breathing in isoflurane-anesthetized rats.2
References/Citations:
- Streit et al. (2011), A Specific Two-pore Domain Potassium Channel Blocker Defines the Structure of the the TASK-1 Open Pore; J. Biol. Chem. 286 13977
- Choski et al. (2015), Breathing Stimulant Compounds Inhibit TASK-3 Potassium Channel Function Likely by Binding at a Common Site in the Channel Pore; Mol. Pharmacol. 88 926
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