A939572 | SCD1 inhibitor
CAS:
1032229-33-6
Catalog Number:
10-4639
Activity:
Potent SCD1 inhibitor
Chemical Names:
4-(2-Chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Molecular Weight:
387.86
Molecular Formula:
C20H22ClN3O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $65.00 | ||
| 25 mg | $225.00 |
This product is also available in the following library:
A939572 (1032229-33-6) is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50s = mouse: <4 nM, human: 37 nM).1 Active in various cancer models alone and in combination with other chemotherapeutics.2-6 A939572 was able to selectively eliminate human pluripotent stem cells (hPSCs) in the presence of progenitor and differentiated cells.7
References/Citations:
- Xin et al. (2008), Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors; Bioorg. Med. Chem. Lett., 18 4298
- Von Roemeling et al. (2013), Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma; Clin. Cancer Res., 19 2368
- Piao et al. (2019), Inhibition of stearoyl CoA desaturase-1 activity suppresses tumour progression and improves prognosis in human bladder cancer; J. Cell Mol. Med., 23 2064
- She et al. (2019), SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals; Cancer Cell Int., 19 103
- Skrypek et al. (2021), Inhibition of Stearoyl-CoA Desaturase Induces the Unfolded Protein Response in Pancreatic Tumors and Suppresses Their Growth; Pancreas, 50 219
- Hu et al. (2022), Inhibition of Stearoyl-CoA Desaturase 1 Potentiates Anti-tumor Activity of Amodiaquine in Non-small Cell Lung Cancer; Biol. Pharm. Bull., 45 438
- Ben-David et al. (2013), Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen; Cell Stem Cell, 12 P167
CAS:
1032229-33-6
Catalog Number:
10-4639
Activity:
Potent SCD1 inhibitor
Chemical Names:
4-(2-Chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide
Molecular Weight:
387.86
Molecular Formula:
C20H22ClN3O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
A939572 (1032229-33-6) is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50s = mouse: <4 nM, human: 37 nM).1 Active in various cancer models alone and in combination with other chemotherapeutics.2-6 A939572 was able to selectively eliminate human pluripotent stem cells (hPSCs) in the presence of progenitor and differentiated cells.7
References/Citations:
- Xin et al. (2008), Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors; Bioorg. Med. Chem. Lett., 18 4298
- Von Roemeling et al. (2013), Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma; Clin. Cancer Res., 19 2368
- Piao et al. (2019), Inhibition of stearoyl CoA desaturase-1 activity suppresses tumour progression and improves prognosis in human bladder cancer; J. Cell Mol. Med., 23 2064
- She et al. (2019), SCD1 is required for EGFR-targeting cancer therapy of lung cancer via re-activation of EGFR/PI3K/AKT signals; Cancer Cell Int., 19 103
- Skrypek et al. (2021), Inhibition of Stearoyl-CoA Desaturase Induces the Unfolded Protein Response in Pancreatic Tumors and Suppresses Their Growth; Pancreas, 50 219
- Hu et al. (2022), Inhibition of Stearoyl-CoA Desaturase 1 Potentiates Anti-tumor Activity of Amodiaquine in Non-small Cell Lung Cancer; Biol. Pharm. Bull., 45 438
- Ben-David et al. (2013), Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen; Cell Stem Cell, 12 P167
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Plymouth Meeting, PA USA
1-855-FOCUS21
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