AA43279 | Nav1.1 activator

CAS:
354812-16-1
Catalog Number:
10-3503
Activity:
Nav1.1 activator
Chemical Name:
3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide
Molecular Weight:
248.30
Molecular Formula:
C12H12N2O2S
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Tan solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$60.00
25 mg$200.00

AA43279 (354812-16-1) is a selective Nav1.1 activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 μM). In rat hippocampal brain slices it increased the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1

References/Citations:

1) Frederiksen et al. (2017), A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo.; Eur. J. Neuroscience, 46 1887

CAS:
354812-16-1
Catalog Number:
10-3503
Activity:
Nav1.1 activator
Chemical Name:
3-Amino-5-(4-methoxyphenyl)thiophene-2-carboxamide
Molecular Weight:
248.30
Molecular Formula:
C12H12N2O2S
Solubility:
Soluble in DMSO (up to 35 mg/ml)
Physical Properties:
Tan solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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