Size: | Price | Quantity | |
---|---|---|---|
5 mg | $60.00 | ||
25 mg | $200.00 |
ABT-263 (923564-51-6) is a potent and selective Bcl-2 family inhibitor / BH3 domain mimetic which binds to Bcl-2, Bcl-xL and Bcl-w (Ki<1 nM). A useful tool compound which has shown interesting results in various cancer clinical trials.2 Synergizes with deoxyglucose and other agents, inducing apoptosis in cancer cells in a xenograft mouse model.3 A novel senolytic agent, inducing apoptosis preferentially in senescent cells in a cell type-restricted manner.4
References/Citations:
1) Tse et al. (2008), ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor; Cancer Res., 68 3421
2) Vogler et al. (2009), Bcl-2 inhibitors: small molecules with a big impact on cancer therapy; Cell Death Differ., 16 360
3) Yamaguchi et al. (2011), Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy; PLoS ONE, 6(9) e24102
4) Zhu et al. (2016), Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors; Aging Cell, 15 428
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ABT-263 (923564-51-6) is a potent and selective Bcl-2 family inhibitor / BH3 domain mimetic which binds to Bcl-2, Bcl-xL and Bcl-w (Ki<1 nM). A useful tool compound which has shown interesting results in various cancer clinical trials.2 Synergizes with deoxyglucose and other agents, inducing apoptosis in cancer cells in a xenograft mouse model.3 A novel senolytic agent, inducing apoptosis preferentially in senescent cells in a cell type-restricted manner.4
References/Citations:
1) Tse et al. (2008), ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor; Cancer Res., 68 3421
2) Vogler et al. (2009), Bcl-2 inhibitors: small molecules with a big impact on cancer therapy; Cell Death Differ., 16 360
3) Yamaguchi et al. (2011), Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy; PLoS ONE, 6(9) e24102
4) Zhu et al. (2016), Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors; Aging Cell, 15 428
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