ABT-869 | Dual VEGFR and PDGFR kinase inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $175.00 |
ABT-869 (796967-16-3) ia a structurally novel, potent inhibitor of receptor tyrosine kinases inhibiting VEGFR and PDGFR and related kinases with IC50s= 3, 4, 4, 66, 3 and 14 nM for VEGFR1, VEGFR2, FLT3, PDGFRβ, CSF-1R and KIT respectively.1,2 Protects cells from necroptosis and rescues SIRS mice from TNF-α-induced shock and death.3 Exerts anti-obesity effects by promoting adipocyte browning.4 Inhibits angiogenesis.5
References/CItations:
- Albert et al. (2006), Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor; Cancer Ther., 5 995
- Guo et al. (2006), Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors; Cancer Ther., 5 1007
- Yu et al. (2023), Repositioning linifanib as a potent anti-necroptosis agent for sepsis; Cell Death Discov., 9 57
- Zhao et al. (2019), Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation; Life Sci., 222 117
- Raoul et al. (2017), An in-depth review of chemical angiogenesis inhibitors for treating hepatocellular carcinoma; Expert Opin. Pharmacother., 18 1467
C21H18FN5O
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
ABT-869 (796967-16-3) ia a structurally novel, potent inhibitor of receptor tyrosine kinases inhibiting VEGFR and PDGFR and related kinases with IC50s= 3, 4, 4, 66, 3 and 14 nM for VEGFR1, VEGFR2, FLT3, PDGFRβ, CSF-1R and KIT respectively.1,2 Protects cells from necroptosis and rescues SIRS mice from TNF-α-induced shock and death.3 Exerts anti-obesity effects by promoting adipocyte browning.4 Inhibits angiogenesis.5
References/CItations:
- Albert et al. (2006), Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor; Cancer Ther., 5 995
- Guo et al. (2006), Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors; Cancer Ther., 5 1007
- Yu et al. (2023), Repositioning linifanib as a potent anti-necroptosis agent for sepsis; Cell Death Discov., 9 57
- Zhao et al. (2019), Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation; Life Sci., 222 117
- Raoul et al. (2017), An in-depth review of chemical angiogenesis inhibitors for treating hepatocellular carcinoma; Expert Opin. Pharmacother., 18 1467
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