ABT-869 | Dual VEGFR and PDGFR kinase inhibitor

CAS:
 796967-16-3
Catalog Number:
 10-5268

Available Options

Size:PriceQuantity 
5 mg$55.00
25 mg$175.00

ABT-869 (796967-16-3) ia a structurally novel, potent inhibitor of receptor tyrosine kinases inhibiting VEGFR and PDGFR and related kinases with IC50s= 3, 4, 4, 66, 3 and 14 nM for VEGFR1, VEGFR2, FLT3, PDGFRβ, CSF-1R and KIT respectively.1,2 Protects cells from necroptosis and rescues SIRS mice from TNF-α-induced shock and death.3 Exerts anti-obesity effects by promoting adipocyte browning.4 Inhibits angiogenesis.5

References/CItations:

  1. Albert et al. (2006), Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor; Cancer Ther., 5 995
  2. Guo et al. (2006), Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors; Cancer Ther., 5 1007
  3. Yu et al. (2023), Repositioning linifanib as a potent anti-necroptosis agent for sepsis; Cell Death Discov., 9 57
  4. Zhao et al. (2019), Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation; Life Sci., 222 117
  5. Raoul et al. (2017), An in-depth review of chemical angiogenesis inhibitors for treating hepatocellular carcinoma; Expert Opin. Pharmacother., 18 1467
CAS:
796967-16-3
Catalog Number:
10-5268
Activity:
Dual VEGFR and PDGFR kinase inhibitor
Chemical Names:
1-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
Alternate Name:
Linifanib
Molecular Weight:
375.41
Molecular Formula:

C21H18FN5O

Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% by HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

20% OFF

For Postdoc
Customers!