AC1903 | TRPC5 blocker
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $70.00 | ||
| 50 mg | $280.00 |
AC1903 (831234-13-0) is a potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis. It also provided therapeutic benefit in a rat model of hypertensive proteineuric kidney disease. The use of this selective tool compound provided a mechanistic rationale for targeting TRPC5 channels in progressive chronic kidney diseases and paves the way for the discovery of new therapeutics. Active in vivo.
References/Citations:
1) Zhou et al. (2017), A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models; Science, 358 1332
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AC1903 (831234-13-0) is a potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis. It also provided therapeutic benefit in a rat model of hypertensive proteineuric kidney disease. The use of this selective tool compound provided a mechanistic rationale for targeting TRPC5 channels in progressive chronic kidney diseases and paves the way for the discovery of new therapeutics. Active in vivo.
References/Citations:
1) Zhou et al. (2017), A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models; Science, 358 1332
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