AdipoRon | Adiponectin agonist
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $50.00 | ||
| 50 mg | $200.00 |
AdipoRon (924416-43-3) is a novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively.1 Displayed similar effects to adiponectin in muscle and liver such as activation of PPARα and AMPK signaling pathways. It also reversed insulin resistance and glucose intolerance in mice on a high-fat diet. AdipoRon ameliorated diabetes in a genetically obese mouse model and prolonged the shortened lifespan of db/db mice on a high-fat diet.1 Attenuates PDGF-induced VSMC proliferation via inhibition of mTPR signaling in an AMPK independent manner.2 Active in vivo.
References/Citations:
1) Okada-Iwabu et al. (2013), A small-molecule AdipoR agonist for type 2 diabetes and short life obesity; Nature 503 493
2) Fairaq et al. (2017), AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia; Pharmacol. Res. 119 289
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AdipoRon (924416-43-3) is a novel potent and selective adiponectin (AdipoR1 and AdipoR2) receptor agonist, Kd=1.8 and 3.1 μM respectively.1 Displayed similar effects to adiponectin in muscle and liver such as activation of PPARα and AMPK signaling pathways. It also reversed insulin resistance and glucose intolerance in mice on a high-fat diet. AdipoRon ameliorated diabetes in a genetically obese mouse model and prolonged the shortened lifespan of db/db mice on a high-fat diet.1 Attenuates PDGF-induced VSMC proliferation via inhibition of mTPR signaling in an AMPK independent manner.2 Active in vivo.
References/Citations:
1) Okada-Iwabu et al. (2013), A small-molecule AdipoR agonist for type 2 diabetes and short life obesity; Nature 503 493
2) Fairaq et al. (2017), AdipoRon, an adiponectin receptor agonist, attenuates PDGF-induced VSMC proliferation through inhibition of mTOR signaling independent of AMPK: Implications toward suppression of neointimal hyperplasia; Pharmacol. Res. 119 289
Related products
-
6BIO | GSK-3 inhibitor
From $65.00CAS:667463-62-9Catalog Number:10-1400Activity:GSK-3 inhibitorChemical Name:(2’Z,3’E)-6-Bromoindirubin-3’oximeMolecular Weight:356.18Molecular Formula:C16H10BrN3O2Solubility:Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 4 mg/ml with warming).Physical Properties:Purple solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.Shipping Code:RT -
A-769662 | AMPK activator
From $72.00CAS:844499-71-4Catalog Number:10-1171Activity:AMPK activatorChemical Name:4-Hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrileMolecular Weight:360.39Molecular Formula:C20H12N2O3SSolubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),Physical Properties:Beige solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT -
KL-001 | Cryptochrome (CRY) activator
From $55.00CAS:309928-48-1Catalog Number:10-1411Activity:Cryptochrome (CRY) activatorChemical Name:N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamideMolecular Weight:398.46Molecular Formula:C21H22N2O4SSolubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml with warming).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
