AE 51310 | OPN4/melanopsin antagonist

CAS:
433966-92-8
Catalog Number:
10-4655
Activity:
OPN4/melanopsin antagonist
Chemical Names:
1-(2,5-Dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine
Molecular Weight:
338.24
Molecular Formula:
C14H17Cl2NO3S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$50.00
25 mg$240.00

AE 51310 (433966-92-8) is a potent antagonist of the GPCR OPN4/melanopsin (Ki = 0.096 nM human OPN4).1 OPN4 regulates circadian rhythms, pupil functions, melatonin expression, cognition, and sleep. OPN4 has been found to bind Ga11 in lung cancer cells modulating PKC activation leading to activation of BRAF/MEK/ERK signaling pathways. AE 51310 decreased the growth and proliferation of both LG17 and LG55 lung cancer tumors in mouse xenograft models.2

References:

  1. Jones et al. (2013), Small-molecule antagonists of melanopsin-mediated phototransduction; Nat. Chem. Biol. 9 630
  2. Wang et al. (2020), Targeting Opsin4/Melanopsin with a Novel Small Molecule Suppresses PKC/RAF/MEK/ERK Signaling and Inhibits Lung Adenocarcinoma Progression; Mol. Cancer Res. 18 1028
CAS:
433966-92-8
Catalog Number:
10-4655
Activity:
OPN4/melanopsin antagonist
Chemical Names:
1-(2,5-Dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine
Molecular Weight:
338.24
Molecular Formula:
C14H17Cl2NO3S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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