Aflatoxin B1 | Mycotoxin

Alfatoxin B1 chemical structure

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Aflatoxin B1 (1162-65-8) is a highly toxic, carcinogenic mycotoxin produced by Aspergillus parasiticus and Aspergillus flavus.1 In the liver Aflatoxin B1 is converted to an epoxide (aflatoxin B1-8,9-epoxide) which is highly reactive and forms conjugates with DNA, RNA, thiols, and proteins.2  Aflatoxin B1 reactive metabolites drive oxidative stress, inflammation and apoptosis.3  Warning: TOXIC. Avoid exposure by all routes.

References/Citations:

  1. Rushing and Selim (2019), Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods; Food Chem. Toxicol. 124 81
  2. McLean and Dutton (1995), Cellular interactions and metabolism of aflatoxin: An update; Pharmacol. Ther. 65 163
  3. Kabali et al. (2026), Alleviation of Aflatoxin B1-Induced Hepatic Damage by Propolis: Effects on Inflammation, Apoptosis, and Cytochrome P450 Enzyme Expression; Curr. Issues Mol. Biol. 48 56
1162-65-8, Aflatoxin, Aflatoxin B1, Aflatoxin B1 supplier

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Aflatoxin B1 (1162-65-8) is a highly toxic, carcinogenic mycotoxin produced by Aspergillus parasiticus and Aspergillus flavus.1 In the liver Aflatoxin B1 is converted to an epoxide (aflatoxin B1-8,9-epoxide) which is highly reactive and forms conjugates with DNA, RNA, thiols, and proteins.2  Aflatoxin B1 reactive metabolites drive oxidative stress, inflammation and apoptosis.3  Warning: TOXIC. Avoid exposure by all routes.

References/Citations:

  1. Rushing and Selim (2019), Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods; Food Chem. Toxicol. 124 81
  2. McLean and Dutton (1995), Cellular interactions and metabolism of aflatoxin: An update; Pharmacol. Ther. 65 163
  3. Kabali et al. (2026), Alleviation of Aflatoxin B1-Induced Hepatic Damage by Propolis: Effects on Inflammation, Apoptosis, and Cytochrome P450 Enzyme Expression; Curr. Issues Mol. Biol. 48 56