AG-1296 | PDGFR kinase inhibitor

CAS:
146535-11-7
Catalog Number:
10-1087
Activity:
PDGFR kinase inhibitor
Chemical Name:
6,7-Dimethoxy-3-phenylquinoxaline
Molecular Weight:
266.3
Molecular Formula:
C16H14N2O2
Solubility:
Soluble in DMSO.
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5mg$60.00
25mg$260.00

AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung cancer cells.

References/Citations:

1) Kovalenko et al. (1997), Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296; Biochemistry, 36 6260
2) Krystal et al. (1997), Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins; Cancer Res., 57 220
3) Strutz et al. (2001), TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2); Kidney Int., 59 579

CAS:
146535-11-7
Catalog Number:
10-1087
Activity:
PDGFR kinase inhibitor
Chemical Name:
6,7-Dimethoxy-3-phenylquinoxaline
Molecular Weight:
266.3
Molecular Formula:
C16H14N2O2
Solubility:
Soluble in DMSO.
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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