AG 1478 | EGFR kinase inhibitor

CAS:
175178-82-2
Catalog Number:
10-2117
Activity:
EGFR kinase inhibitor
Chemical Name:
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine, free base
Molecular Weight:
315.76
Molecular Formula:
C16H14ClN3O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
AG 1478 Supplier | CAS 175178-82-2 | Focus Biomolecules

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size :PriceQuantity 
5 mg$50.00
25 mg$150.00

AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines.1,2 AG-1478 reduces pulmonary fibrosis in a rat model.3 Cell permeable.

References/Citations:

1) Han et al. (1996), Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors; Cancer Res., 56 3859
2) Partik et al. (1999), Inhibition of epidermal-growth-factor-receptor-dependent signaling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro; J. Cancer Res. Clin. Oncol., 125 379
3) Rice et al. (1999), Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats; Am. J. Pathol., 155 213

CAS:
175178-82-2
Catalog Number:
10-2117
Activity:
EGFR kinase inhibitor
Chemical Name:
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine, free base
Molecular Weight:
315.76
Molecular Formula:
C16H14ClN3O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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