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AG 1478 | EGFR kinase inhibitor

AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines1,2. AG-1478 reduces pulmonary fibrosis in a rat model3. Cell permeable.

References/Citations
1) Han et al. (1996), Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors; Cancer Res., 56 3859
2) Partik et al. (1999), Inhibition of epidermal-growth-factor-receptor-dependent signaling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro; J. Cancer Res. Clin. Oncol., 125 379
3) Rice et al. (1999), Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats; Am. J. Pathol., 155 213

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Focus Biomolecules cell signaling reagent supplier, chemical structure of AG 1478 | EGFR kinase inhibitor | CAS 175178-82-2

Catalog#  10-2117

$50.00
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CAS:
175178-82-2
Catalog Number:
10-2117
Activity:
EGFR kinase inhibitor
Chemical Name:
N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine, free base
Molecular Weight:
315.76
Molecular Formula:
C16H14ClN3O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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