AG-1517 HCl | EGFR kinase inhibitor

CAS:
153436-54-5
Catalog Number:
10-1377
Activity:
EGFR kinase inhibitor
Alternate Names:
PD153,053; SU-5271; Z-252868
Chemical Name:
4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride
Molecular Weight:
360.21
Molecular Formula:
C16H14BrN3O2
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
AG-1517 HCl Supplier | CAS 153436-54-5 | Focus Biomolecules

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5 mg$70.00
25 mg$290.00

AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.1 Inhibits the growth of a number of cancer cell lines.2 AG-1517 HCl is an extremely useful tool for exploring EGF-mediated cellular signaling.3

References/Citations:

1) Fry et al. (1994), A specific inhibitor of the epidermal growth factor receptor tyrosine kinase; Science, 265 1093
2) Bos et al. (1997), PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner; Clin. Cancer Res., 3 2099
3) Tetreault et al. (2008), Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayers; J. Cell. Biochem., 105 1240

CAS:
153436-54-5
Catalog Number:
10-1377
Activity:
EGFR kinase inhibitor
Alternate Names:
PD153,053; SU-5271; Z-252868
Chemical Name:
4-(3-Bromoanilino)-6,7-dimethoxyquinazoline hydrochloride
Molecular Weight:
360.21
Molecular Formula:
C16H14BrN3O2
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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