Alsterpaullone | GSK-3ß inhibitor

CAS:
237430-03-4
Catalog Number:
10-1397
Activity:
GSK3β inhibitor, CDK5/p25 inhibitor
Chemical Name:
9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one
Molecular Weight:
293.28
Molecular Formula:
C16H11N3O3
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Brown solid
Purity:
96% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
1 mg$56.00
5 mg$224.00

Alsterpaullone (237430-03-4) is a potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM).1 Alsterpaullone induces apoptosis2 and inhibits angiogenesis3.

References/Citations:

1) Bain et al. (2003), The specificities of protein kinase inhibitors: an update; Biochem. J., 371 199
2) Lahusen et al. (2003), Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential; Mol. Carcinog., 36 183
3) Zahler et al. (2010), Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro; Angiogenesis, 13 239

CAS:
237430-03-4
Catalog Number:
10-1397
Activity:
GSK3β inhibitor, CDK5/p25 inhibitor
Chemical Name:
9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one
Molecular Weight:
293.28
Molecular Formula:
C16H11N3O3
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Brown solid
Purity:
96% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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