Altretamine | Ferroptosis inducer
CAS:
645-05-6
Catalog Number:
10-5592
Activity:
Ferroptosis inducer/GPX4 inhibitor
Chemical Names:
N2,N2,N4,N4,N6,N6-Hexamethyl-1,3,5-triazine-2,4,6-triamine; 2,4,6-Tris(dimethylamino)-1,3,5-triazine
Alternate Name:
Hexamethylmelamine; NSC-13875
Molecular Weight:
210.29
Molecular Formula:
C9H18N6
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 20 mg | $35.00 | ||
| 100 mg | $100.00 |
Altretamine (645-05-6) induces ferroptosis by inhibiting glutathione peroxidase 4 (GPX4) which causes accumulation of lipid hydroperoxides.1 Ferroptosis induction may be its mechanism of action as a cancer chemotherapeutic.2 Clinically useful agent for ovarian cancer.3,4
References/Citations:
- Woo et al. (2015), Elucidating Compound Mechanism of Action by Network Perturbation Analysis; Cell, 162 441
- Ye et al. (2021), The mechanisms and therapeutic targets of ferroptosis in cancer; Expert Opin. Ther. Targets, 25 965
- Alberts et al. (2004), Long-term follow-up of a phase II trial of oral altretamine for consolidation of clinical complete remission in women with stage III epithelial ovarian cancer in the Southwest Oncology Group; Int. J. Gynecol. Cancer, 14 224
- Chan et al. (2004), Oral altretamine used as salvage therapy in recurrent ovarian cancer; Gynecol. Oncol., 92 368
CAS:
645-05-6
Catalog Number:
10-5592
Activity:
Ferroptosis inducer/GPX4 inhibitor
Chemical Names:
N2,N2,N4,N4,N6,N6-Hexamethyl-1,3,5-triazine-2,4,6-triamine; 2,4,6-Tris(dimethylamino)-1,3,5-triazine
Alternate Name:
Hexamethylmelamine; NSC-13875
Molecular Weight:
210.29
Molecular Formula:
C9H18N6
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
White solid
Purity:
>98% TLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Altretamine (645-05-6) induces ferroptosis by inhibiting glutathione peroxidase 4 (GPX4) which causes accumulation of lipid hydroperoxides.1 Ferroptosis induction may be its mechanism of action as a cancer chemotherapeutic.2 Clinically useful agent for ovarian cancer.3,4
References/Citations:
- Woo et al. (2015), Elucidating Compound Mechanism of Action by Network Perturbation Analysis; Cell, 162 441
- Ye et al. (2021), The mechanisms and therapeutic targets of ferroptosis in cancer; Expert Opin. Ther. Targets, 25 965
- Alberts et al. (2004), Long-term follow-up of a phase II trial of oral altretamine for consolidation of clinical complete remission in women with stage III epithelial ovarian cancer in the Southwest Oncology Group; Int. J. Gynecol. Cancer, 14 224
- Chan et al. (2004), Oral altretamine used as salvage therapy in recurrent ovarian cancer; Gynecol. Oncol., 92 368
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