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Product Details

Amlexanox | TBK1 inhibitor / Antidiabetic

Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models.1 Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity.  Inhibits TANK-binding kinase 1 (TBK1) and IKKε (IC50=1.2 μM).2 Clinically useful in the treatment of aphthus ulcers.3 Inhibits prostate tumor metastasis by targeting IKKε/TBK1/NFκB signaling.4

References/Citations
1) Koch et al. (2013), Obesity: Teaching an old drug new tricks - amlexanox targets inflammation to improve metabolic dysfunction; Nat. Rev. Endocrinol., 9 185
2) Reilly et al. (2013), An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in mice; Nat. Med., 19 313
3) Nasry et al. (2016), Different modalities for treatment of recurrent aphthous stromatitis. A Randomized clinical trial; J. Clin. Exp. Dent. 8 e517
4) Cheng et al. (2018), Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKε/TBK1/NFκB signaling; Theranostics 8 4633

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Amlexanox | 68302-57-8 | Structure | Supplier

Catalog#  10-1435

$40.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
68302-57-8
Catalog Number:
10-1435
Activity:
TBK1 inhibitor / Antidiabetic
Chemical Name:
2-Amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid
Molecular Weight:
298.29
Molecular Formula:
C16H14N2O4
Solubility:
Soluble in DMSO (up to 60 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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