Amlodipine | L-type Ca channel blocker
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 250 mg | $30.00 | ||
| 500 mg | $55.00 |
Amlodipine (88150-42-9) is an anti-hypertensive L-type calcium channel blocker, which also benefits the cardiovascular system by stimulating nitric oxide synthase, inhibiting angiotensin-induced oxidative stress and cardiovascular injury, and inhibiting monocyte/endothelial adhesion. Amlodipine also has a longer duration of action as compared to other similar calcium channel blockers.
References/Citations:
1) Mason et al. (2003), Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine; Arterioscler. Thromb. Vasc. Biol., 23 2155
2) Asano et al. (2003), A calcium channel blocker activates both ecto-5(‘)-nucleotidase and NO synthase in HUVEC; Biochem. Biophys. Res. Commun., 311 625
3) Yu et al. (2003), Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction; Hypertension, 42 329
4) Zhou et al. (2004), Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats; Am. J. Hypertension, 17 167
5) Ueda et al. (1993), A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects; Br. J. Clin. Pharmacol., 36 561
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Amlodipine (88150-42-9) is an anti-hypertensive L-type calcium channel blocker, which also benefits the cardiovascular system by stimulating nitric oxide synthase, inhibiting angiotensin-induced oxidative stress and cardiovascular injury, and inhibiting monocyte/endothelial adhesion. Amlodipine also has a longer duration of action as compared to other similar calcium channel blockers.
References/Citations:
1) Mason et al. (2003), Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine; Arterioscler. Thromb. Vasc. Biol., 23 2155
2) Asano et al. (2003), A calcium channel blocker activates both ecto-5(‘)-nucleotidase and NO synthase in HUVEC; Biochem. Biophys. Res. Commun., 311 625
3) Yu et al. (2003), Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction; Hypertension, 42 329
4) Zhou et al. (2004), Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats; Am. J. Hypertension, 17 167
5) Ueda et al. (1993), A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects; Br. J. Clin. Pharmacol., 36 561
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