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Product Details

Amlodipine | L-type Ca channel blocker

Amlodipine (88150-42-9) is an anti-hypertensive L-type calcium channel blocker, which also benefits the cardiovascular system by stimulating nitric oxide synthase, inhibiting angiotension-induced oxidative stress and cardiovascular injury, and inhibiting monocyte/endothelial adhesion. Amlodipine also has a longer duration of action as compared to other similar calcium channel blockers.

1) Mason et al. (2003), Novel vascular biology of third-generation L-type calcium channel antagonists: ancillary actions of amlodipine; Arterioscler. Thromb. Vasc. Biol., 23 2155
2) Asano et al. (2003), A calcium channel blocker activates both ecto-5(Ô)-nucleotidase and NO synthase in HUVEC; Biochem. Biophys. Res. Commun., 311 625
3) Yu et al. (2003), Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction; Hypertension, 42 329
4) Zhou et al. (2004), Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats; Am. J. Hypertension, 17 167
5) Ueda et al. (1993), A comparative assessment of the duration of action of amlodipine and nifedipine GITS in normotensive subjects; Br. J. Clin. Pharmacol., 36 561

Focus Biomolecules cell signaling reagent supplier, structure of Amlodipine | L-type Ca channel blocker | CAS 88150-42-9

Catalog#  10-1210-0250

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Catalog Number:
L-type Ca channel blocker
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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