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Simvastatin | HMG-CoA reductase inhibitor

Simvastatin (79902-63-9) is a synthetic analog of lovastatin (cat.# 10-1222). Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase1,2. Simvastatin induces apoptosis in various cell lines and causes cell cycle arrest in early G1 phase. Clinically useful antilipemic agent3.

References/Citations
1) Merck 14:8539
2) Hancock et al. (1989), All ras proteins are polyisoprenylated but only some are palmitoylated; Cell, 57 1167
3) Ose et al. (2000), Lipid-altering efficacy and safety of simvastatin 80 mg/day: long-term experience in a large group of patients with hypercholesterolemia. World Wide Expanded Dose Simvastatin Study Group Clin. Cardiol. 23 39
4) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]

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Focus Biomolecules cell signaling reagent supplier, structure Simvastatin | HMG-CoA reductase inhibitor | CAS 79902-63-9

Catalog#  10-1018-0100

$50.00
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CAS:
79902-63-9
Catalog Number:
10-1018
Activity:
HMG-CoA reductase inhibitor
Alternate Names:
Mevinolin
Chemical Name:
2,2-Dimethyl-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid
Molecular Weight:
418.58
Molecular Formula:
C25H38O5
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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