Amphotericin B | Antifungal agent

CAS:
1397-89-3
Catalog Number:
10-2430
Activity:
Antifungal agent
Chemical Names:
NSC 527017
Molecular Weight:
924.08
Molecular Formula:
C47H73NO17
Solubility:
Soluble in DMSO (18 mg/ml)
Physical Properties:
Yellow or orange solid
Purity:
90% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
1 g$60.00
5 g$240.00

Amphotericin B (1397-89-3) is a powerful antimycotic, effective against a wide variety of fungi, including yeast, via two mechanisms: forming pores in the plasma membrane, leading to leakage and death1, and causing oxidative stress2. Other mechanisms have more recently been proposed, including formation of intracellular amphotericin B-containing vesicular bodies that target vacuoles.3 Amphotericin B is also effective against some parasites, such as Leishmania spp.4 Because of its potency and broad-spectrum activity, it is a common additive used to maintain sterility in cell culture and viral transport media.

References:

  1. Kinsky et al. (1970), Antibiotic interaction with model membranes; Annu. Rev. Pharmacol., 10 119
  2. Sokol-Anderson et al. (1986), Amphotericin B-Induced Oxidative Damage and Killing of Candida Albicans; Infect. Dis., 154 75
  3. Grela et al. (2019), Modes of the antibiotic activity of amphotericin B against Candida albicans; Rep., 9 17029
  4. Paila et al. (2010), Amphotericin B inhibits entry of Leishmaniz donovani into primary macrophages; Biophys. Res. Commun., 399 429
CAS:
1397-89-3
Catalog Number:
10-2430
Activity:
Antifungal agent
Chemical Names:
NSC 527017
Molecular Weight:
924.08
Molecular Formula:
C47H73NO17
Solubility:
Soluble in DMSO (18 mg/ml)
Physical Properties:
Yellow or orange solid
Purity:
90% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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