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Product Details

ANA-12 | TrkB antagonist

ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively. Systemic administration to adult mice decreased TrkB activity in the brain without affecting neuronal survival or altering TrkA and TrkC functions. ANA-12 displays antidepressant and anxiolytic properties in mouse models after systemic administration.1 Shows antidepressant effects on LPS-induced depression-like behavior in mice.2 ANA-12 has been used to elucidate the role of BDNF in improvement of cognitive decline during calorie restriction3 and in the discovery of new neurotrophic agents4.

1) Cazorla et al. (2011), Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice; J. Clin. Invest., 121 1846
2) Zhang et al. (2014), Antidepressant effects of TRKB ligands on depression-like behavior and dendritic changes in mice after inflammation; J. Neuropsychopharmacol., 18 pyu077
3) Kishi et al. (2015), Calorie restriction improves cognitive decline via up-regulation of brain-derived neurotrophic factor: tropomyosin-related kinase B in hippocampus of obesity-induced hypertensive rats; Int. Heart J., 56 110
4) Chakravarty et al. (2015) A novel natural product inspired scaffold with robust neurotrophic, neurogenic and neuroprotective action; Sci. Rep., 5 14134

Focus Biomolecules cell signaling reagent supplier, chemical structure of ANA-12 | TrkB antagonist | CAS 219766-25-3

Catalog#  10-2828

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Catalog Number:
TrkB antagonist
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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