Anacardic Acid | HAT inhibitor

CAS:
16611-84-0
Catalog Number:
10-4015
Activity:
HAT inhibitor
Chemical Name:
2-Hydroxy-6-pentadecylbenzoic acid
Alternate Names:
6-Pentadecylsalicylic acid; 6-PDSA
Molecular Weight:
348.52
Molecular Formula:
C22H36O3
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$40.00
25 mg$150.00

Anacardic acid (16611-84-0) is a natural product found in cashew nut oil.  It is an inhibitor of the histone acetyltransferases p300 and PCAF (IC50’s = 8.5 and 5.0 µM respectively).1  Anacardic acid sensitizes cancer cells to ionizing radiation2 and suppresses proteins involved in invasion and angiogenesis (Src/FAK/Rho GTPases3 and MMP’s 2 (IC50 = 11.11 µM)4 and 9).  It inhibits both inducible and constitutive NF-κB activation.5

References/Citations:

1) Balasubramanyam et al. (2003), Small molecule modulators of histone acetyltransferase p300; J. Biol. Chem. 278 19134
2) Sun et al. (2006), Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation; FEBS Lett. 580 4353
3) Wu et al. (2011), Anacardic acid (6-Pentadecylsalicylic acid) Inhibits Tumor Angiogenesis by Targeting Src/FAK/Rho GTPases Signaling Pathway; J. Pharmacol. Exp. Ther. 339 403
4) Omanakuttan et al. (2012), Anacardic acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9; Mol. Pharmacol. 82 614
5) Sung et al. (2008), Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kB- regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kBα kinase, leading to potentiation of apoptosis; Blood 111 4880

CAS:
16611-84-0
Catalog Number:
10-4015
Activity:
HAT inhibitor
Chemical Name:
2-Hydroxy-6-pentadecylbenzoic acid
Alternate Names:
6-Pentadecylsalicylic acid; 6-PDSA
Molecular Weight:
348.52
Molecular Formula:
C22H36O3
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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