Anagrelide HCl | PDE3 inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $48.00 | ||
| 50 mg | $200.00 |
Anagrelide HCl (58579-51-4) is a potent and selective phosphodiesterase (PDE3) inhibitor, IC50=36 nM).1 Inhibits platelet production by disrupting megakaryocyte maturation2 via a mechanism which is independent of PDE3 inhibition3. Clinically useful agent for conditions requiring platelet lowering therapy.4,5
References/Citations:
1) Gilespie et al. (1988), Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity; Biochem. Pharmacol. 37 2866
2) Mazur et al. (1992), Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans; Blood, 79 1931
3) Wang et al. (2005), Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures; Br. J. Pharmacol., 146 324
4) Barbui et al. (2012), Front-line therapy in polycythemia vera and essential thrombocythemia; Blood Rev., 26 205
5) Chen et al. (2012), Platelet-lowering therapy with anagrelide as an adjuvant therapy for treatment of primary pulmonary neoplasm-associated extreme thrombocytosis; Jpn. J. Clin. Oncol., 42 761
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Anagrelide HCl (58579-51-4) is a potent and selective phosphodiesterase (PDE3) inhibitor, IC50=36 nM).1 Inhibits platelet production by disrupting megakaryocyte maturation2 via a mechanism which is independent of PDE3 inhibition3. Clinically useful agent for conditions requiring platelet lowering therapy.4,5
References/Citations:
1) Gilespie et al. (1988), Anagrelide: a potent and selective inhibitor of platelet cyclic AMP phosphodiesterase enzyme activity; Biochem. Pharmacol. 37 2866
2) Mazur et al. (1992), Analysis of the mechanism of anagrelide-induced thrombocytopenia in humans; Blood, 79 1931
3) Wang et al. (2005), Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures; Br. J. Pharmacol., 146 324
4) Barbui et al. (2012), Front-line therapy in polycythemia vera and essential thrombocythemia; Blood Rev., 26 205
5) Chen et al. (2012), Platelet-lowering therapy with anagrelide as an adjuvant therapy for treatment of primary pulmonary neoplasm-associated extreme thrombocytosis; Jpn. J. Clin. Oncol., 42 761
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