Ansamitocin P3 | Microtubule depolymerizer

CAS:
66584-72-3
Catalog Number:
10-2199
Activity:
Microtubule depolymerizer
Molecular Weight:
635.16
Molecular Formula:
C32H43ClN2O9
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming).
Physical Properties:
White solid
Purity:
>90% by TLC, remainder is P-1, P-2 and P-4.
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
1 mg$50.00
5 mg$120.00

Ansamitocin P3 (66584-72-3) is a fungal metabolite from Actinosynnema pretiosum which binds to the phomopsin A/rhizoxin site on tubulin.1,2 Ansamitocin P3 is a maytansine analog which displays potent cytotoxicity against various human tumor cell lines.2,3 Maytansine and its analogs cause extensive disassembly of microtubules and totally prevent tubulin spiralization.4

References/Citations:

1) Li et al (1992) Binding selectivity of rhizoxin, phomopsin A, vinblastine and ansamitocin P-3 to fungal tubulins: differential interactions of thes antimitotic agents with brain and fungal tubulins; Biochem. Biophys. Res. Commun., 187 722
2) Venghateri et al. (2013) Ansamitocin P3 Depolymerizes Microtubules and Induces Apoptosis by Binding Tubulin at the Vinblastine Site; PLoS ONE 8 e75182
3) Suwanborirux et al. (1990) Ansamitocin P-3, a maytansinoid, from claopodium crispifolium and anomodo attenuates or associated actinomycetes; Experientia, 46 117
4) Ootsu et al. (1980) Effects of new antimitotic antibiotics, ansamitocins, on the growth of murine tumors in vivo and on the assembly of microtubules in vitro; Cancer Res. 40 1707

CAS:
66584-72-3
Catalog Number:
10-2199
Activity:
Microtubule depolymerizer
Molecular Weight:
635.16
Molecular Formula:
C32H43ClN2O9
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml with warming).
Physical Properties:
White solid
Purity:
>90% by TLC, remainder is P-1, P-2 and P-4.
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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